SOAP II

Comparison of Dopamine and Norepinephrine in the Treatment of Shock (2010)

Design: Multicenter, RCT

P N = 1679
I Dopamine
*If BP could not be maintained with a dose of 20ug/kg of body weight for dopamine, open label NE, epinephrine or vasopressin could be added
C Norepinephrine
*If BP could not be maintained with a dose of 0.19ug/kg of body weight for NE, open label NE, epinephrine or vasopressin could be added
O Primary outcome: rate of death at 28 days

  • NSS for rate of death
  • Sub-group analysis: dopamine associated with increased rate of death at 28 days among cardiogenic shock, but not septic or hypovolemic shock

Safety:

  • More arrhythmic events among the patients treated with dopamine
    (24.1% vs. 12.4%, p<0.001)

Take-away points:

  • In cardiogenic shock, norepinephrine is associated with less death at 28 days than dopamine
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